Publications - AIDA, the AI solution to fight gastric cancer

Publications

Achievements

Showcasing Our Research Excellence: Key Publications, Deliverables and Milestones

Publications

2023
García-Morales, N., et al. Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management. J Clin Med. 12(13):4363.
Jonaitis, P., Nyssen, O.P., Saracino, I.M. et al. Comparison of the management of Helicobacter pylori infection between the older and younger European populations. Sci Rep 13, 17235 (2023).
Southern, J., Gonzalez, G., Borgas, P. et al. Genomic-driven nutritional interventions for radiotherapy-resistant rectal cancer patient. Sci Rep 13, 14862 (2023). https://doi.org/10.1038/s41598-023-41833-8

2024
Kerdegari, H., Higgins, K., Veselkov, D., Laponogov, I., Polaka, I., Coimbra, M., Pescino, J. A., Leja, M., Kanonnikoff, T. F., & Veselkov, K. (2024). Foundational Models for Pathology and Endoscopy Images: Application for Gastric Inflammation. ArXiv.
Pabón-Carrasco M., (…), Moreira L., Nyssen O.P., Mégraud F., O'Morain C., Gisbert J.P. Hp-EuReg Investigators. Role of proton pump inhibitors dosage and duration in Helicobacter pylori eradication treatment: Results from the European Registry on H. pylori management. United European Gastroenterol J. 2024;12(1):122-138. doi: 10.1002/ueg2.12476.
Bujanda L, Nyssen OP, Ramos J, Bordin DS, Tepes B, Perez-Aisa A, Pavoni M, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Phull PS, Buzás GM, Machado JC, Boltin D, Boyanova L, Tonkić A, Marlicz W, Venerito M, Vologzanina L, Fadieienko GD, Fiorini G, Resina E, Muñoz R, Cano-Català A, Puig I, García-Morales N, Hernández L, Moreira L, Megraud F, Morain CO, Montes M, Gisbert JP; Hp-EuReg investigators; Hp-EuReg investigators. Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance. Am J Gastroenterol. 2024;119(4):646-654. doi: 10.14309/ajg.0000000000002600.
Martínez-Domínguez SJ, Nyssen OP, Lanas Á, Alfaro E, Jonaitis L, Mahmudov U, Voynovan I, Gülüstan B, Rodrigo L, Fiorini G, Perez-Aisa Á, Tejedor-Tejada J, Tepes B, Vologzanina L, Mammadov E, Lerang F, Oğlu QFV, Bakulina NV, Abdulkhakov R, Tatiana I, Butler TJ, Sarsenbaeva AS, Bumane R, Lucendo AJ, Romano M, Bujanda L, Abdulkhakov SR, Zaytsev O, Pabón-Carrasco M, Keco-Huerga A, Denkovski M, Huguet JM, Perona M, Núñez Ó, Pavoni M, Fadieienko G, Alekseenko S, Smith SM, Hernández L, Kupcinskas J, Bordin DS, Leja M, Gasbarrini A, Gridnyev O, Cano-Català A, Parra P, Moreira L, Mégraud F, O'Morain C, Gisbert JP; Hp‐EuReg Investigators. Indications of Helicobacter pylori Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp-EuReg). Helicobacter. 2024 Jul-Aug;29(4):e13111. doi: 10.1111/hel.13111. Erratum in: Helicobacter. 2024 Jul-Aug;29(4):e13124. doi: 10.1111/hel.13124.
Huguet JM, Ferrer-Barceló L, Suárez P, Barcelo-Cerda S, Sempere J, Saracino IM, et al. Role of compliance in Helicobacter pylori eradication treatment: results of the European Registry on H. pylori management. United European Gastroenterol J. 2024; 12(6): 691–704. https://doi.org/10.1002/ueg2.12569.
Olmedo L, Calvet X, Gené E, Bordin DS, Voynovan I, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Perez-Aisa Á, Lucendo AJ, Rodrigo L, Sarsenbaeva AS, Khlinov IB, Fadieienko G, Zaytsev O, Lanas Á, Martínez-Domínguez SJ, Alfaro E, Jonaitis L, Núñez Ó, Pellicano R, Hernández L, Gridnyev O, Kupcinskas J, Gasbarrini A, Boltin D, Niv Y, Babayeva G, Marcos-Pinto R, Tepes B, Venerito M, Papp V, Lerang F, Leja M, Phull PS, Marlicz W, Doulberis M, Smith SM, Milivojevic V, Kunovsky L, Mestrovic A, Matysiak-Budnik T, Simsek H, Cano-Català A, Puig I, Moreira L, Parra P, Nyssen OP, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg investigators*. Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut. 2024 Dec 10;74(1):15-25. doi: 10.1136/gutjnl-2024-332804.
Babayeva GH, Mahmudov UR, Mammadov EE, Guliyev FV, Verdiyev EKh, Machanov UR, Ibishov RF, Huseynov HM, Zalov ZS, Ismayilova SY, Hasanov RA, Ibrahimli HI, CanoCatalà A, Parra P, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. EFFECTIVENESS OF FIRST-LINE EMPIRICAL TREATMENT IN AZERBAIJAN: RESULTS FROM THE EUROPEAN REGISTRY ON HELICOBACTER PYLORI MANAGEMENT (HP-EUREG). Journal of Medicine and Science. 2024; №2 (36), 34-47 DOI: 10.61775/2413-3302.v2i36.06
Viegas MI, Areia M and Elvas L et al. Effectiveness of First-Line Empirical Treatment in Portugal: Data from the European Registry on Helicobacter pylori Management. GE Port J Gastroenterol. 2024. Vol. 32(5):339-349. https://doi.org/10.1159/000543179
Kerdegari H, Higgins K, Veselkov D, Laponogov I, Polaka I, Coimbra M, Pescino JA, Leja M, Dinis-Ribeiro M, Fleitas Kanonnikoff T, et al. Foundational Models for Pathology and Endoscopy Images: Application for Gastric Inflammation. Diagnostics. 2024; 14(17):1912. https://doi.org/10.3390/diagnostics14171912

2025
Higgins, K., Nyssen, O.P., Southern, J. et al. The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations. Nat Commun 16, 6472 (2025). https://doi.org/10.1038/s41467-025-61329-5
Nunes FC, Aguieiras C, (...); Mateus TL. Molecular Detection of Multiple Antimicrobial Resistance Genes in Helicobacter pylori-Positive Gastric Samples from Patients Undergoing Upper Gastrointestinal Endoscopy with Gastric Biopsy in Algarve, Portugal. Aug 1 2025. ANTIBIOTICS-BASEL 14(8) https://doi.org/10.1159/000543179
Smith SM, Nyssen OP, FitzGerald R, Butler TJ, McNamara D, Qasim A, Costigan C, Cano-Catalá A, Parra P, Moreira L, et al. First-Line Prescriptions and Effectiveness of Helicobacter pylori Eradication Treatment in Ireland over a 10-Year Period: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg). Antibiotics. 2025;14(7):680.  https://doi.org/10.3390/antibiotics14070680
Doulberis M, Riva D, Linas I, Mosler P, Völler T, Jallouli I, Knuchel J, Gregoriano C, Gressot P, Gkretzios T, Kiosses C, Balanis T, Tutuian R, Kulaksiz H, Cano-Català A, Parra P, Moreira L, P Nyssen O, Megraud F, O' Morain C, Kuntzen T, P Gisbert J. Effectiveness and safety of first-line empirical Helicobacter pylori eradication regimens in Switzerland: an interim analysis from a prospective multicentre registry (Hp-EuReg). Swiss Med Wkly. 2025 Jul 14;155:4191. https://doi.org/10.57187/s.4191
Tepes B, Denkovski M, Jurecic NB, Tepes K, Cano-Català A, Parra P, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. Second- and Third-Line Therapies for Helicobacter pylori Eradication in Slovenia: Data From 2013-2023 of the European Registry on H. pylori Management. Helicobacter. 2025 Sep-Oct;30(5):e70085. doi: 10.1111/hel.70085
Almeida E, Martins ML, Marques D, Delas R, Almeida T, Chaves J, Libânio D, Renna F, Coimbra MT, Dinis-Ribeiro M. Artificial intelligence for endoscopic grading of gastric intestinal metaplasia: advancing risk stratification for gastric cancer. Endoscopy. 2025 Nov;57(11):1254-1260. doi: 10.1055/a-2657-9906
Lopes, C., Brandão, A., Teixeira, M.R. et al. Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets. Sci Rep 15, 18491 (2025). https://doi.org/10.1038/s41598-025-96864-0

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Funded by the European Union under the Horizon Europe Framework Programme Grant Agreement Nº: 101095359. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Commission. Neither the European Union nor the European Health and Digital Executive Agency can be held responsible for them.

Supported by the UK Research and Innovation
(Grant Agreement Nº: 10058099)

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